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Establishment of reference intervals of biochemical analytes for healthy Chinese volunteers during the screening process in clinical pharmacology trials

Establishment of reference intervals of biochemical analytes for healthy Chinese volunteers during the screening process in clinical pharmacology trials

Objectives: The laboratory reference intervals (gathering) plays a key role in clinical pharmacology trials, both in the screening process and in evaluating drug safety. However, the get-togethers tend to be confined to the general population, and data on residents get-togethers for a limited trial. The purpose of this study was to determine the appropriate get-togethers for use when screening specifically defined subgroups of healthy Chinese population in clinical pharmacology trials.


Methods: A total of 773 healthy Chinese volunteers (552 men and 221 women) who try to participate in clinical pharmacology trials were included in this study. Sixteen different biochemical analytes measured by Beckman Coulter Unicel DXC 800 automatic analyzer. Get-togethers, which are partitioned by gender using the Harris and Boyd and calculated using non-parametric methods.


Results: gatherings of 16 analytes biochemical for a healthy Chinese volunteers during the screening process in clinical pharmacology trials reported in this study. striking differences between get-togethers in this study and gathering provided by our laboratory or the existing literature was also observed. Compared with our institutional gatherings, get-togethers newly established more applicable to the population of the current session.


Conclusion: The get-together in this study can serve as a powerful clinical tool for the screening process in clinical pharmacology trials. However, these gatherings should be re-verified if any circumstances change. These results also emphasize the importance of rebuilding the gatherings are more applicable for testing local population.

Establishment of reference intervals of biochemical analytes for healthy Chinese volunteers during the screening process in clinical pharmacology trials
Establishment of reference intervals of biochemical analytes for healthy Chinese volunteers during the screening process in clinical pharmacology trials

False, marked leukocytosis in 2 cats with Heinz body hemolytic anemia

Two domestic shorthair cat presented with anorexia and dehydration after intake of caramelized onions. Delivering the key findings from the CBC (ADVIA 2120), serum biochemistry, and urinalysis including counterfeit, marked leukocytosis with discordant basophils (BASO) channel and channel number WBC peroxidase, the directions normal leukocyte number, light, anemia non-regenerative the difference between automatic and the number of reticulocytes, the abundance of large Heinz body (HBs), and scattergrams very irregular.

Case 1 also shows the concentration was significantly increased average living cell hemoglobin (MCHC) and the difference between the index of RBC hemoglobin. Results leukocytes fake confirmed through re-analysis of samples (including the acquisition of new samples, use an analysis of alternatives (Sysmex XT-2000iV; Case 1 only), and evaluation of scattergrams and blood films (Cases 1 and 2).

Repeatedly the number of discrepant reticulocytes also identified . in both cases, the wrong number of BASO WBC, the difference in the number of reticulocytes and index of RBC, and scattergrams atypical interpreted with results from the various effects of HBs, these cases emphasize the importance of reviewing the film of blood, interpret scattergrams, and usefulness of the method duplicates to determine various measurands on a hematology analyzer.

Cefuroxime Sodium
C023-1G 1 g
EUR 145.2

Cefuroxime Sodium
C023-5G 5 g
EUR 402

Cefuroxime (sodium)
HY-B1256 1g
EUR 192

Cefuroxime
GA9610-100MG 100 mg
EUR 84

Cefuroxime
GA9610-1G 1 g
EUR 187.2

Cefuroxime
GA9610-250MG 250 mg
EUR 112.8

Cefuroxime
GA9610-1 1
EUR 125.1

Cefuroxime
GA9610-100 100
EUR 39.4

Cefuroxime
GA9610-250 250
EUR 63.3

Cefuroxime Axetil (USP grade powder)
51R-U098220 350 mg
EUR 603.6
Description: Cefuroxime Axetil (USP grade powder) chemical reference substance

Cefuroxime Axetil d-3 iso (USP grade powder)
51R-U098231 10 mg
EUR 1975.2
Description: Cefuroxime Axetil d-3 iso (USP grade powder) chemical reference substance

Cefazolin Sodium Salt
B1530-1G each
EUR 170.4

Cefazolin Sodium Salt
B1530-5G each
EUR 430.8

Cefazolin (sodium salt)
C4183-1000 1 g
EUR 201.6
Description: Cefazolin is a semisynthetic antibiotic with a broad spectrum of antibacterial activity. Cefazolin has exhibited high activity against Gram-positive bacteria and Gram-negative bacteria [1].

Cefazolin (sodium salt)
C4183-250 250 mg
EUR 126
Description: Cefazolin is a semisynthetic antibiotic with a broad spectrum of antibacterial activity. Cefazolin has exhibited high activity against Gram-positive bacteria and Gram-negative bacteria [1].

Cefazolin (sodium salt)
C4183-5.1 10 mM (in 1mL DMSO)
EUR 135.6
Description: Cefazolin is a semisynthetic antibiotic with a broad spectrum of antibacterial activity. Cefazolin has exhibited high activity against Gram-positive bacteria and Gram-negative bacteria [1].

Cefazolin (sodium salt)
C4183-500 500 mg
EUR 165.6
Description: Cefazolin is a semisynthetic antibiotic with a broad spectrum of antibacterial activity. Cefazolin has exhibited high activity against Gram-positive bacteria and Gram-negative bacteria [1].

Cefoxitin (sodium salt)
C4849-1000 1 g
EUR 289.2
Description: Cefoxitin (sodium salt) is a second generation cephalosporin antibiotic that was used to treat a wide range of gram-negative and gram-positive bacteria [1][2].

Cefoxitin (sodium salt)
C4849-250 250 mg
EUR 135.6
Description: Cefoxitin (sodium salt) is a second generation cephalosporin antibiotic that was used to treat a wide range of gram-negative and gram-positive bacteria [1][2].

Cefoxitin (sodium salt)
C4849-500 500 mg
EUR 196.8
Description: Cefoxitin (sodium salt) is a second generation cephalosporin antibiotic that was used to treat a wide range of gram-negative and gram-positive bacteria [1][2].

Cefonicid (sodium salt)
C3812-1000 1 g
EUR 487.2
Description: Cefonicid is a second-generation cephalosporin antibiotic.Cephalosporins, the largest and most diverse family of antibiotics of the beta-lactam group, are structurally and pharmacologically related to the penicillins.

Cefonicid (sodium salt)
C3812-5.1 10 mM (in 1mL DMSO)
EUR 135.6
Description: Cefonicid is a second-generation cephalosporin antibiotic.Cephalosporins, the largest and most diverse family of antibiotics of the beta-lactam group, are structurally and pharmacologically related to the penicillins.

Cefonicid (sodium salt)
C3812-500 500 mg
EUR 301.2
Description: Cefonicid is a second-generation cephalosporin antibiotic.Cephalosporins, the largest and most diverse family of antibiotics of the beta-lactam group, are structurally and pharmacologically related to the penicillins.

Cefoxitin Sodium Salt
B1892-1G each
EUR 222

Cefoxitin Sodium Salt
B1892-500 each
EUR 157.2

Cefoxitin Sodium Salt
B1892-5G each
EUR 692.4

Cefoxitin sodium salt
GA4412-1G 1 g
EUR 132

Cefoxitin sodium salt
GA4412-250MG 250 mg
EUR 74.4

Cefoxitin sodium salt
GA4412-5G 5 g
EUR 351.6

Cefazolin sodium salt
GA4751-1G 1 g
EUR 103.2

Cefazolin sodium salt
GA4751-5G 5 g
EUR 208.8

Ceftiofur sodium salt
GA9758-1G 1 g
EUR 132

Cefapirin sodium salt
GP5306-1G 1 g
EUR 189.6

Cefapirin sodium salt
GP5306-250MG 250 mg
EUR 103.2

Ceftiofur sodium salt
GA9758-1 1
EUR 67.9

Cefoxitin sodium salt
GA4412-1 1
EUR 79.1

Cefoxitin sodium salt
GA4412-250 250
EUR 31.7

Cefoxitin sodium salt
GA4412-5 5
EUR 261

Cefazolin sodium salt
GA4751-1 1
EUR 55.4

Cefazolin sodium salt
GA4751-5 5
EUR 142.4

Cefapirin sodium salt
GP5306-1 1
EUR 126.5

Cefapirin sodium salt
GP5306-250 250
EUR 55.4

Cefotaxime Sodium Salt
abx188641-100g 100 g
EUR 610.8

Cefsulodin (sodium salt)
C5593-1000 1 g
EUR 268.8
Description: Cefsulodin, formerly named as SCE-129, is a cephalosporin with a spectrum of antibacterial activity against Staphylococcus aureus, Pseudomonas aeruginosa, and most other gram-positive cocci [1].

Cefsulodin (sodium salt)
C5593-250 250 mg
EUR 147.6
Description: Cefsulodin, formerly named as SCE-129, is a cephalosporin with a spectrum of antibacterial activity against Staphylococcus aureus, Pseudomonas aeruginosa, and most other gram-positive cocci [1].

Cefsulodin (sodium salt)
C5593-500 500 mg
EUR 216
Description: Cefsulodin, formerly named as SCE-129, is a cephalosporin with a spectrum of antibacterial activity against Staphylococcus aureus, Pseudomonas aeruginosa, and most other gram-positive cocci [1].

Cefotaxime (sodium salt)
C4588-1000 1 g
EUR 151.2
Description: MIC: <0.1 ?g/ml for S. pneumoniae Cefotaxime is a cephalosporin antibiotic.

Cefotaxime (sodium salt)
C4588-5.1 10 mM (in 1mL DMSO)
EUR 135.6
Description: MIC: <0.1 ?g/ml for S. pneumoniae Cefotaxime is a cephalosporin antibiotic.

Cefotaxime (sodium salt)
C4588-500 500 mg
EUR 129.6
Description: MIC: <0.1 ?g/ml for S. pneumoniae Cefotaxime is a cephalosporin antibiotic.

Cefotaxime (sodium salt)
C4588-5000 5 g
EUR 181.2
Description: MIC: <0.1 ?g/ml for S. pneumoniae Cefotaxime is a cephalosporin antibiotic.

Cefotaxime Sodium Salt
20-abx082178
  • EUR 260.40
  • EUR 210.00
  • 100 mg
  • 5 g

Cefotaxime sodium salt
GA3583-1G 1 g
EUR 132

Cefotaxime sodium salt
GA3583-25G 25 g
EUR 600

Cefotaxime sodium salt
GA3583-5G 5 g
EUR 217.2

Cefditoren sodium salt
GA4627-1G 1 g
EUR 753.6

Cefotaxime (sodium salt)
HY-A0088 10mM/1mL
EUR 135.6

Cefotaxime sodium salt
GA3583-1 1
EUR 60.3

Cefotaxime sodium salt
GA3583-25 25
EUR 372.8

Cefotaxime sodium salt
GA3583-5 5
EUR 135.6

Cefditoren sodium salt
GA4627-1 1
EUR 593.3

Cefamandole sodium salt
C079-100MG 100 mg
EUR 177.6

Cefamandole sodium salt
C079-500MG 500 mg
EUR 568.8

Cefamandole (sodium salt)
C3541-100 100 mg
EUR 292.8
Description: MIC: 0.25-2 mg/L for different E. coli strainsCefamandole is a cephalosporin antibiotic.The cephalosporins are a class of ?-lactam antibiotics originally derived from the fungus Acremonium, which was previously known as "Cephalosporium".

Cefamandole (sodium salt)
C3541-50 50 mg
EUR 182.4
Description: MIC: 0.25-2 mg/L for different E. coli strainsCefamandole is a cephalosporin antibiotic.The cephalosporins are a class of ?-lactam antibiotics originally derived from the fungus Acremonium, which was previously known as "Cephalosporium".

Cefamandole (sodium salt)
C3541-500 500 mg
EUR 710.4
Description: MIC: 0.25-2 mg/L for different E. coli strainsCefamandole is a cephalosporin antibiotic.The cephalosporins are a class of ?-lactam antibiotics originally derived from the fungus Acremonium, which was previously known as "Cephalosporium".

Ceftizoxime sodium salt
GA1247-1G 1 g
EUR 98.4

Ceftizoxime sodium salt
GA1247-250MG 250 mg
EUR 70.8

Cefpodoxime sodium salt
GA7534-100MG 100 mg
EUR 648

Ceftriaxone (sodium salt)
HY-B0712B 500mg
EUR 207.6

Cefamandole sodium salt
GA9567-100 100
EUR 75.3

Cefamandole sodium salt
GA9567-500 500
EUR 248.6

Ceftizoxime sodium salt
GA1247-1 1
EUR 51.4

Ceftizoxime sodium salt
GA1247-250 250
EUR 28.4

Cefmetazole sodium salt
GA4116-1 1
EUR 113.1

Cefmetazole sodium salt
GA4116-250 250
EUR 37.7

Cefpodoxime sodium salt
GA7534-100 100
EUR 506.2

Cefoperazone (sodium salt)
C3913-10000 10 g
EUR 483.6
Description: Cefoperazone is a new semisynthetic cephalosporin with a broad spectrum of antibacterial activity. Cefoperazone shows high activity against gram-positive bacteria and gram-negative bacilli, such as Escherichia coli, Klebsiella pneumoniae, and Proteus species [1].

Cefoperazone (sodium salt)
C3913-5000 5 g
EUR 320.4
Description: Cefoperazone is a new semisynthetic cephalosporin with a broad spectrum of antibacterial activity. Cefoperazone shows high activity against gram-positive bacteria and gram-negative bacilli, such as Escherichia coli, Klebsiella pneumoniae, and Proteus species [1].

Cefoperazone sodium salt
GA8838-1G 1 g
EUR 69.6

Cefoperazone sodium salt
GA8838-25G 25 g
EUR 246

Cefoperazone sodium salt
GA8838-5G 5 g
EUR 122.4

Cefoperazone (sodium salt)
HY-B0210A 500mg
EUR 129.6

Cefoperazone sodium salt
GA8838-1 1
EUR 27.8

Cefoperazone sodium salt
GA8838-25 25
EUR 174

Cefoperazone sodium salt
GA8838-5 5
EUR 71.1

Cefsulodin Sodium Salt, Hydrate
B1512-1G each
EUR 314.4

Cefsulodin Sodium Salt, Hydrate
B1512-250 each
EUR 157.2

Cefsulodin Sodium Salt, Hydrate
B1512-5G each
EUR 966

Cefsulodin sodium salt hydrate
GA1461-1G 1 g
EUR 141.6

Cefsulodin sodium salt hydrate
GA1461-250MG 250 mg
EUR 93.6

Cefsulodin sodium salt hydrate
GA1461-5G 5 g
EUR 476.4

Cefsulodin sodium salt hydrate
GA1461-1 1
EUR 87.1

Cefsulodin sodium salt hydrate
GA1461-250 250
EUR 47.4

Cefsulodin sodium salt hydrate
GA1461-5 5
EUR 363.8

MES SODIUM SALT
213002 each Ask for price

XTT, sodium salt
PB2525 250mg
EUR 323.09

MES, sodium salt
MB0611 50g
EUR 89.23

XTT sodium salt
GC5281-100MG 100 mg
EUR 246

XTT sodium salt
GC5281-250MG 250 mg
EUR 390

XTT sodium salt
GC5281-25MG 25 mg
EUR 112.8

XTT sodium salt
GC5281-50MG 50 mg
EUR 170.4

MES sodium salt
GB1926-100G 100 g
EUR 132

MES sodium salt
GB1926-10G 10 g
EUR 60

MES sodium salt
GB1926-250G 250 g
EUR 217.2

MES sodium salt
GB1926-25G 25 g
EUR 74.4

MES sodium salt
GB1926-500G 500 g
EUR 357.6

TES sodium salt
GB4016-100G 100 g
EUR 180

TES sodium salt
GB4016-250G 250 g
EUR 322.8

TES sodium salt
GB4016-25G 25 g
EUR 84

TES sodium salt
GB4016-500G 500 g
EUR 514.8

BES sodium salt
GB9133-100G 100 g
EUR 217.2

BES sodium salt
GB9133-250G 250 g
EUR 409.2

BES sodium salt
GB9133-25G 25 g
EUR 103.2

MES sodium salt
GB1926-10 10
EUR 19.8

MES sodium salt
GB1926-100 100
EUR 79.1

MES sodium salt
GB1926-25 25
EUR 31.7

MES sodium salt
GB1926-250 250
EUR 150.4

MES sodium salt
GB1926-500 500
EUR 265.8

TES sodium salt
GB4016-100 100
EUR 118.7

TES sodium salt
GB4016-25 25
EUR 39.4

TES sodium salt
GB4016-250 250
EUR 237.2

TES sodium salt
GB4016-500 500
EUR 395.5

BES sodium salt
GB9133-100 100
EUR 150.4

BES sodium salt
GB9133-25 25
EUR 55.4

BES sodium salt
GB9133-250 250
EUR 308.5

XTT sodium salt
GC5281-100 100
EUR 174

XTT sodium salt
GC5281-25 25
EUR 63.3

XTT sodium salt
GC5281-250 250
EUR 292.5

XTT sodium salt
GC5281-50 50
EUR 110.7

MOPS SODIUM SALT
213004 each Ask for price

NADP, sodium salt
2737-100 each
EUR 183.6

NADP, sodium salt
2737-1000 each
EUR 940.8

NADP, sodium salt
2737-500 each
EUR 548.4

CHPG Sodium salt
B7475-10 10 mg
EUR 303.6

CHPG Sodium salt
B7475-50 50 mg
EUR 1082.4

CAPS, sodium salt
CB0097 50g
EUR 86.1

MOPS, sodium salt
MDB360S 100g
EUR 106.98

TAPS sodium salt
GB0912-100G 100 g
EUR 160.8

TAPS sodium salt
GB0912-25G 25 g
EUR 74.4

TAPS sodium salt
GB0912-500G 500 g
EUR 409.2

MOPS sodium salt
GB8397-100G 100 g
EUR 79.2

MOPS sodium salt
GB8397-1KG 1 kg
EUR 308.4

MOPS sodium salt
GB8397-250G 250 g
EUR 124.8

MOPS sodium salt
GB8397-25G 25 g
EUR 58.8

MOPS sodium salt
GB8397-500G 500 g
EUR 193.2

DIDS sodium salt
HY-D0086 50mg
EUR 170.4

NADP (sodium salt)
HY-F0002 500mg
EUR 325.2

TAPS, sodium salt
TB0920 50g
EUR 86.1

PNPP sodium salt
GX9577-25 25
EUR 151.6

PNPP sodium salt
GX9577-5 5
EUR 46.6

TAPS sodium salt
GB0912-100 100
EUR 102.7

TAPS sodium salt
GB0912-25 25
EUR 31.7

TAPS sodium salt
GB0912-500 500
EUR 308.5

MOPS sodium salt
GB8397-1 1
EUR 225.3

MOPS sodium salt
GB8397-100 100
EUR 35.5

MOPS sodium salt
GB8397-25 25
EUR 19

MOPS sodium salt
GB8397-250 250
EUR 73.5

MOPS sodium salt
GB8397-500 500
EUR 129.7

HEPES SODIUM SALT
208002 each Ask for price

Hepes, Sodium Salt
CH039 25 g
EUR 141.6

Hepes, Sodium Salt
CH040 100 g
EUR 202.8

Hepes, Sodium Salt
CH041 500 g
EUR 448.8

HEPES Sodium salt
B7303-250000 250 g
EUR 343.2

PIPES Sodium Salt
20-abx082438
  • EUR 326.40
  • EUR 226.80
  • 250 g
  • 25 g

CAPSO, sodium salt
CD0041 50g
EUR 91.32

PIPES, sodium salt
PDB0434 100g
EUR 105.94

MOPSO, sodium salt
MDB0095 25g
EUR 76.7

TAPSO sodium salt
GB1759-100G 100 g
EUR 160.8

TAPSO sodium salt
GB1759-25G 25 g
EUR 74.4

MOPSO sodium salt
GB3228-100G 100 g
EUR 112.8

MOPSO sodium salt
GB3228-250G 250 g
EUR 180

MOPSO sodium salt
GB3228-25G 25 g
EUR 69.6

MOPSO sodium salt
GB3228-500G 500 g
EUR 274.8

CAPSO sodium salt
GB4515-100G 100 g
EUR 132

CAPSO sodium salt
GB4515-250G 250 g
EUR 246

CAPSO sodium salt
GB4515-25G 25 g
EUR 64.8

CAPSO sodium salt
GB4515-500G 500 g
EUR 370.8

DIPSO sodium salt
GB8985-100G 100 g
EUR 394.8

DIPSO sodium salt
GB8985-250G 250 g
EUR 753.6

DIPSO sodium salt
GB8985-25G 25 g
EUR 180

HEPES sodium salt
GB9181-100G 100 g
EUR 84

HEPES sodium salt
GB9181-1KG 1 kg
EUR 274.8

HEPES sodium salt
GB9181-250G 250 g
EUR 118.8

HEPES sodium salt
GB9181-25G 25 g
EUR 64.8

HEPES sodium salt
GB9181-500G 500 g
EUR 180

GJ103 (sodium salt)
HY-101203A 10mM/1mL
EUR 170.4

HEPES, sodium salt
HB0265 50g
EUR 78.79

TAPSO, sodium salt
TB0922 50g
EUR 122.64

TAPSO sodium salt
GB1759-100 100
EUR 102.7

TAPSO sodium salt
GB1759-25 25
EUR 31.7


Data from 1164 patients admitted to our Department of Urology from January 2011 to July 2013 were retrospectively reviewed; 714 patients (age, 5-87 years; male: female ratio, 1.8: 1) exhibited urolithiasis, and 450 patients (age, 12-94 years; male: female ratio, 3.8: 1). Blood and urine are collected from patients morning after hospital admission. Serum and urine parameters examined by automatic biochemical analyzer. Statistical analyzes including Mann-Whitney U test and binary logistic regression.

Madeline

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