Establishment of reference intervals of biochemical analytes for healthy Chinese volunteers during the screening process in clinical pharmacology trials
Objectives: The laboratory reference intervals (gathering) plays a key role in clinical pharmacology trials, both in the screening process and in evaluating drug safety. However, the get-togethers tend to be confined to the general population, and data on residents get-togethers for a limited trial. The purpose of this study was to determine the appropriate get-togethers for use when screening specifically defined subgroups of healthy Chinese population in clinical pharmacology trials.
Methods: A total of 773 healthy Chinese volunteers (552 men and 221 women) who try to participate in clinical pharmacology trials were included in this study. Sixteen different biochemical analytes measured by Beckman Coulter Unicel DXC 800 automatic analyzer. Get-togethers, which are partitioned by gender using the Harris and Boyd and calculated using non-parametric methods.
Results: gatherings of 16 analytes biochemical for a healthy Chinese volunteers during the screening process in clinical pharmacology trials reported in this study. striking differences between get-togethers in this study and gathering provided by our laboratory or the existing literature was also observed. Compared with our institutional gatherings, get-togethers newly established more applicable to the population of the current session.
Conclusion: The get-together in this study can serve as a powerful clinical tool for the screening process in clinical pharmacology trials. However, these gatherings should be re-verified if any circumstances change. These results also emphasize the importance of rebuilding the gatherings are more applicable for testing local population.
Establishment of reference intervals of biochemical analytes for healthy Chinese volunteers during the screening process in clinical pharmacology trials
False, marked leukocytosis in 2 cats with Heinz body hemolytic anemia
Two domestic shorthair cat presented with anorexia and dehydration after intake of caramelized onions. Delivering the key findings from the CBC (ADVIA 2120), serum biochemistry, and urinalysis including counterfeit, marked leukocytosis with discordant basophils (BASO) channel and channel number WBC peroxidase, the directions normal leukocyte number, light, anemia non-regenerative the difference between automatic and the number of reticulocytes, the abundance of large Heinz body (HBs), and scattergrams very irregular.
Case 1 also shows the concentration was significantly increased average living cell hemoglobin (MCHC) and the difference between the index of RBC hemoglobin. Results leukocytes fake confirmed through re-analysis of samples (including the acquisition of new samples, use an analysis of alternatives (Sysmex XT-2000iV; Case 1 only), and evaluation of scattergrams and blood films (Cases 1 and 2).
Repeatedly the number of discrepant reticulocytes also identified . in both cases, the wrong number of BASO WBC, the difference in the number of reticulocytes and index of RBC, and scattergrams atypical interpreted with results from the various effects of HBs, these cases emphasize the importance of reviewing the film of blood, interpret scattergrams, and usefulness of the method duplicates to determine various measurands on a hematology analyzer.
Description: Selective leukocyte elastase inhibitor (IC50 = 44 nM) that displays no activity at a range of other proteases. Inhibits NF-?B activation and LTB4-induced neutrophil transmigration in vitro.
Description: Selective leukocyte elastase inhibitor (IC50 = 44 nM) that displays no activity at a range of other proteases. Inhibits NF-?B activation and LTB4-induced neutrophil transmigration in vitro.
Description: Selective leukocyte elastase inhibitor (IC50 = 44 nM) that displays no activity at a range of other proteases. Inhibits NF-?B activation and LTB4-induced neutrophil transmigration in vitro.
Description: Selective leukocyte elastase inhibitor (IC50 = 44 nM) that displays no activity at a range of other proteases. Inhibits NF-?B activation and LTB4-induced neutrophil transmigration in vitro.
Description: IC50: Inhibit protein phosphatase types 2A (PP2A) and 4 (PP4) intensively with an IC50 of 1.5 nM and 3 nM respectively. Inhibit topoisomerase II (Topo II) and protein phosphatase type 1 (PP1) slightly with an IC50 of 40 ?M and 131 ?M respectively.
Description: IC50: Inhibit protein phosphatase types 2A (PP2A) and 4 (PP4) intensively with an IC50 of 1.5 nM and 3 nM respectively. Inhibit topoisomerase II (Topo II) and protein phosphatase type 1 (PP1) slightly with an IC50 of 40 ?M and 131 ?M respectively.
Description: Integrase inhibitors are a new class of antiretroviral drugs blocking the action of HIV integrase, which catalyses several key steps in the life cycle of the virus and is essential for insertion of the viral genome into the host cell DNA. GSK1349572 is a next-generation HIV integrase (IN) inhibitor.
Description: Integrase inhibitors are a new class of antiretroviral drugs blocking the action of HIV integrase, which catalyses several key steps in the life cycle of the virus and is essential for insertion of the viral genome into the host cell DNA. GSK1349572 is a next-generation HIV integrase (IN) inhibitor.
Description: Integrase inhibitors are a new class of antiretroviral drugs blocking the action of HIV integrase, which catalyses several key steps in the life cycle of the virus and is essential for insertion of the viral genome into the host cell DNA. GSK1349572 is a next-generation HIV integrase (IN) inhibitor.
Description: Integrase inhibitors are a new class of antiretroviral drugs blocking the action of HIV integrase, which catalyses several key steps in the life cycle of the virus and is essential for insertion of the viral genome into the host cell DNA. GSK1349572 is a next-generation HIV integrase (IN) inhibitor.
Description: The non-fluorescent resazurin has been used as a fluorogenic oxidation-reduction indicator in various cells by flow cytometry, fluorescence microscopy and high-throughput screening. Its red-fluorescent product, resorufin, has absorption/emission maxima ~575/585 nm.
Description: The non-fluorescent resazurin has been used as a fluorogenic oxidation-reduction indicator in various cells by flow cytometry, fluorescence microscopy and high-throughput screening. Its red-fluorescent product, resorufin, has absorption/emission maxima ~575/585 nm.
Description: Entacapone, a nitrocatechol compound, is a selective and reversible inhibitor of catechol-O-methyltransferase (COMT), a Mg2+-dependent enzyme involved in the metabolism of catecholamines and catechol compounds.
Description: Entacapone, a nitrocatechol compound, is a selective and reversible inhibitor of catechol-O-methyltransferase (COMT), a Mg2+-dependent enzyme involved in the metabolism of catecholamines and catechol compounds.
Description: Entacapone, a nitrocatechol compound, is a selective and reversible inhibitor of catechol-O-methyltransferase (COMT), a Mg2+-dependent enzyme involved in the metabolism of catecholamines and catechol compounds.
Description: Nigericin sodium salt is an ionophore that exchanges K+ for H+ across biological membranes.Ionophore is a lipid-soluble molecule that transports ions across the cell membrane.
Description: Nigericin sodium salt is an ionophore that exchanges K+ for H+ across biological membranes.Ionophore is a lipid-soluble molecule that transports ions across the cell membrane.
Description: Nigericin sodium salt is an ionophore that exchanges K+ for H+ across biological membranes.Ionophore is a lipid-soluble molecule that transports ions across the cell membrane.
Description: The antibiotic bialaphos (or SF1293) is a natural non-selective phytotoxin produced by Streptomyces hygroscopicus. Bialaphos is a tripeptide consisting of two L-alanine molecules and an L-glutamic acid analogue called phosphinothricin.
Description: The antibiotic bialaphos (or SF1293) is a natural non-selective phytotoxin produced by Streptomyces hygroscopicus. Bialaphos is a tripeptide consisting of two L-alanine molecules and an L-glutamic acid analogue called phosphinothricin.
Description: Methicillin is a semisynthetic penicillin antibiotic.In vitro: Similar to other ?-lactam antibiotics, meticillin acts via inhibiting the synthesis of bacterial cell walls.
Description: Methicillin is a semisynthetic penicillin antibiotic.In vitro: Similar to other ?-lactam antibiotics, meticillin acts via inhibiting the synthesis of bacterial cell walls.
Description: Methicillin is a semisynthetic penicillin antibiotic.In vitro: Similar to other ?-lactam antibiotics, meticillin acts via inhibiting the synthesis of bacterial cell walls.
Description: Methicillin is a semisynthetic penicillin antibiotic.In vitro: Similar to other ?-lactam antibiotics, meticillin acts via inhibiting the synthesis of bacterial cell walls.
Description: Ertapenem, the first group of carbapenems, is a 1-?-methyl carbapenem with potent in vitro activity against a broad spectrum of bacterial pathogens including Gram-positive and Gram-negative aerobic and anaerobic pathogens [1].
Description: Ertapenem, the first group of carbapenems, is a 1-?-methyl carbapenem with potent in vitro activity against a broad spectrum of bacterial pathogens including Gram-positive and Gram-negative aerobic and anaerobic pathogens [1].
Description: Ertapenem, the first group of carbapenems, is a 1-?-methyl carbapenem with potent in vitro activity against a broad spectrum of bacterial pathogens including Gram-positive and Gram-negative aerobic and anaerobic pathogens [1].
Description: MIC: 0.25-2 mg/L for different E. coli strainsCefamandole is a cephalosporin antibiotic.The cephalosporins are a class of ?-lactam antibiotics originally derived from the fungus Acremonium, which was previously known as "Cephalosporium".
Description: MIC: 0.25-2 mg/L for different E. coli strainsCefamandole is a cephalosporin antibiotic.The cephalosporins are a class of ?-lactam antibiotics originally derived from the fungus Acremonium, which was previously known as "Cephalosporium".
Description: MIC: 0.25-2 mg/L for different E. coli strainsCefamandole is a cephalosporin antibiotic.The cephalosporins are a class of ?-lactam antibiotics originally derived from the fungus Acremonium, which was previously known as "Cephalosporium".
Description: Cefoxitin (sodium salt) is a second generation cephalosporin antibiotic that was used to treat a wide range of gram-negative and gram-positive bacteria [1][2].
Description: Cefoxitin (sodium salt) is a second generation cephalosporin antibiotic that was used to treat a wide range of gram-negative and gram-positive bacteria [1][2].
Description: Cefoxitin (sodium salt) is a second generation cephalosporin antibiotic that was used to treat a wide range of gram-negative and gram-positive bacteria [1][2].
Description: Fosmidomycin is a specific inhibitor of 1-deoxy-d-xylulose 5-phosphate reductoisomerase (DXP) [1]. Fosmidomycin is an antibiotic originally isolated from bacteria of the genus Streptomyces.
Description: Fosmidomycin is a specific inhibitor of 1-deoxy-d-xylulose 5-phosphate reductoisomerase (DXP) [1]. Fosmidomycin is an antibiotic originally isolated from bacteria of the genus Streptomyces.
Description: Fosmidomycin is a specific inhibitor of 1-deoxy-d-xylulose 5-phosphate reductoisomerase (DXP) [1]. Fosmidomycin is an antibiotic originally isolated from bacteria of the genus Streptomyces.
Description: Ki: 0.12 nMSimvastatin is a HMG-CoA reductase inhibitor. HMG-CoA reductase has been found to be the rate-limiting enzyme in the cholesterol biosynthetic pathway and the target of the ?statin? class of cholesterol-lowering drugs.
Description: Ki: 0.12 nMSimvastatin is a HMG-CoA reductase inhibitor. HMG-CoA reductase has been found to be the rate-limiting enzyme in the cholesterol biosynthetic pathway and the target of the ?statin? class of cholesterol-lowering drugs.
Description: Moniliformin induces mitotic arrest at the metaphase stage.Mitosis is a part of the cell cycle when replicated chromosomes are separated into two new nuclei.
Description: IC50: 3.2 ?M: blocks NF-?B signaling via inhibition of I?B? phosphorylationNarasin, isolated from certain Streptomyces sp. is an ionophore antibiotic.
Description: IC50: 3.2 ?M: blocks NF-?B signaling via inhibition of I?B? phosphorylationNarasin, isolated from certain Streptomyces sp. is an ionophore antibiotic.
Description: Moxalactam (sodium salt) is a ?-lactam antibiotic.?-lactam antibiotics (beta-lactam antibiotics) are a class of broad-spectrum antibiotics that contain a beta-lactam ring in their molecular structures. Most ?-lactam antibiotics act by inhibiting cell wall biosynthesis.
Description: Moxalactam (sodium salt) is a ?-lactam antibiotic.?-lactam antibiotics (beta-lactam antibiotics) are a class of broad-spectrum antibiotics that contain a beta-lactam ring in their molecular structures. Most ?-lactam antibiotics act by inhibiting cell wall biosynthesis.
Description: Moxalactam (sodium salt) is a ?-lactam antibiotic.?-lactam antibiotics (beta-lactam antibiotics) are a class of broad-spectrum antibiotics that contain a beta-lactam ring in their molecular structures. Most ?-lactam antibiotics act by inhibiting cell wall biosynthesis.
Description: Moxalactam (sodium salt) is a ?-lactam antibiotic.?-lactam antibiotics (beta-lactam antibiotics) are a class of broad-spectrum antibiotics that contain a beta-lactam ring in their molecular structures. Most ?-lactam antibiotics act by inhibiting cell wall biosynthesis.
Description: Cefazolin is a semisynthetic antibiotic with a broad spectrum of antibacterial activity. Cefazolin has exhibited high activity against Gram-positive bacteria and Gram-negative bacteria [1].
Description: Cefazolin is a semisynthetic antibiotic with a broad spectrum of antibacterial activity. Cefazolin has exhibited high activity against Gram-positive bacteria and Gram-negative bacteria [1].
Description: Cefazolin is a semisynthetic antibiotic with a broad spectrum of antibacterial activity. Cefazolin has exhibited high activity against Gram-positive bacteria and Gram-negative bacteria [1].
Description: Cefazolin is a semisynthetic antibiotic with a broad spectrum of antibacterial activity. Cefazolin has exhibited high activity against Gram-positive bacteria and Gram-negative bacteria [1].
Description: Tazobactam is a ?-lactamase inhibitor [1]. Tazobactam shows intrinsic activity against Acinetobacter strains. The ?-Lactamases are responsible for resistance to penicillins, extended-spectrum cephalosporins, monobactams, and carbapenems.
Description: Tazobactam is a ?-lactamase inhibitor [1]. Tazobactam shows intrinsic activity against Acinetobacter strains. The ?-Lactamases are responsible for resistance to penicillins, extended-spectrum cephalosporins, monobactams, and carbapenems.
Description: Tazobactam is a ?-lactamase inhibitor [1]. Tazobactam shows intrinsic activity against Acinetobacter strains. The ?-Lactamases are responsible for resistance to penicillins, extended-spectrum cephalosporins, monobactams, and carbapenems.
Description: Cefonicid is a second-generation cephalosporin antibiotic.Cephalosporins, the largest and most diverse family of antibiotics of the beta-lactam group, are structurally and pharmacologically related to the penicillins.
Description: Cefonicid is a second-generation cephalosporin antibiotic.Cephalosporins, the largest and most diverse family of antibiotics of the beta-lactam group, are structurally and pharmacologically related to the penicillins.
Description: Cefonicid is a second-generation cephalosporin antibiotic.Cephalosporins, the largest and most diverse family of antibiotics of the beta-lactam group, are structurally and pharmacologically related to the penicillins.
Description: Cefoperazone is a new semisynthetic cephalosporin with a broad spectrum of antibacterial activity. Cefoperazone shows high activity against gram-positive bacteria and gram-negative bacilli, such as Escherichia coli, Klebsiella pneumoniae, and Proteus species [1].
Description: Cefoperazone is a new semisynthetic cephalosporin with a broad spectrum of antibacterial activity. Cefoperazone shows high activity against gram-positive bacteria and gram-negative bacilli, such as Escherichia coli, Klebsiella pneumoniae, and Proteus species [1].
Description: Cefsulodin, formerly named as SCE-129, is a cephalosporin with a spectrum of antibacterial activity against Staphylococcus aureus, Pseudomonas aeruginosa, and most other gram-positive cocci [1].
Description: Cefsulodin, formerly named as SCE-129, is a cephalosporin with a spectrum of antibacterial activity against Staphylococcus aureus, Pseudomonas aeruginosa, and most other gram-positive cocci [1].
Description: Cefsulodin, formerly named as SCE-129, is a cephalosporin with a spectrum of antibacterial activity against Staphylococcus aureus, Pseudomonas aeruginosa, and most other gram-positive cocci [1].
Description: Furegrelate (sodium salt) is a potent inhibitor of thromboxane synthase [1][2].Thromboxane A synthase 1 (platelet, cytochrome P450, family 5, subfamily A) is a cytochrome P450 enzyme that catalyzes the conversion of prostaglandin H2 to thromboxane A2.
Description: Furegrelate (sodium salt) is a potent inhibitor of thromboxane synthase [1][2].Thromboxane A synthase 1 (platelet, cytochrome P450, family 5, subfamily A) is a cytochrome P450 enzyme that catalyzes the conversion of prostaglandin H2 to thromboxane A2.
Description: Furegrelate (sodium salt) is a potent inhibitor of thromboxane synthase [1][2].Thromboxane A synthase 1 (platelet, cytochrome P450, family 5, subfamily A) is a cytochrome P450 enzyme that catalyzes the conversion of prostaglandin H2 to thromboxane A2.
Data from 1164 patients admitted to our Department of Urology from January 2011 to July 2013 were retrospectively reviewed; 714 patients (age, 5-87 years; male: female ratio, 1.8: 1) exhibited urolithiasis, and 450 patients (age, 12-94 years; male: female ratio, 3.8: 1). Blood and urine are collected from patients morning after hospital admission. Serum and urine parameters examined by automatic biochemical analyzer. Statistical analyzes including Mann-Whitney U test and binary logistic regression.
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