Establishment of reference intervals of biochemical analytes for healthy Chinese volunteers during the screening process in clinical pharmacology trials

Establishment of reference intervals of biochemical analytes for healthy Chinese volunteers during the screening process in clinical pharmacology trials

Objectives: The laboratory reference intervals (gathering) plays a key role in clinical pharmacology trials, both in the screening process and in evaluating drug safety. However, the get-togethers tend to be confined to the general population, and data on residents get-togethers for a limited trial. The purpose of this study was to determine the appropriate get-togethers for use when screening specifically defined subgroups of healthy Chinese population in clinical pharmacology trials.


Methods: A total of 773 healthy Chinese volunteers (552 men and 221 women) who try to participate in clinical pharmacology trials were included in this study. Sixteen different biochemical analytes measured by Beckman Coulter Unicel DXC 800 automatic analyzer. Get-togethers, which are partitioned by gender using the Harris and Boyd and calculated using non-parametric methods.


Results: gatherings of 16 analytes biochemical for a healthy Chinese volunteers during the screening process in clinical pharmacology trials reported in this study. striking differences between get-togethers in this study and gathering provided by our laboratory or the existing literature was also observed. Compared with our institutional gatherings, get-togethers newly established more applicable to the population of the current session.


Conclusion: The get-together in this study can serve as a powerful clinical tool for the screening process in clinical pharmacology trials. However, these gatherings should be re-verified if any circumstances change. These results also emphasize the importance of rebuilding the gatherings are more applicable for testing local population.

 Establishment of reference intervals of biochemical analytes for healthy Chinese volunteers during the screening process in clinical pharmacology trials
Establishment of reference intervals of biochemical analytes for healthy Chinese volunteers during the screening process in clinical pharmacology trials

False, marked leukocytosis in 2 cats with Heinz body hemolytic anemia

Two domestic shorthair cat presented with anorexia and dehydration after intake of caramelized onions. Delivering the key findings from the CBC (ADVIA 2120), serum biochemistry, and urinalysis including counterfeit, marked leukocytosis with discordant basophils (BASO) channel and channel number WBC peroxidase, the directions normal leukocyte number, light, anemia non-regenerative the difference between automatic and the number of reticulocytes, the abundance of large Heinz body (HBs), and scattergrams very irregular.

Case 1 also shows the concentration was significantly increased average living cell hemoglobin (MCHC) and the difference between the index of RBC hemoglobin. Results leukocytes fake confirmed through re-analysis of samples (including the acquisition of new samples, use an analysis of alternatives (Sysmex XT-2000iV; Case 1 only), and evaluation of scattergrams and blood films (Cases 1 and 2).

Repeatedly the number of discrepant reticulocytes also identified . in both cases, the wrong number of BASO WBC, the difference in the number of reticulocytes and index of RBC, and scattergrams atypical interpreted with results from the various effects of HBs, these cases emphasize the importance of reviewing the film of blood, interpret scattergrams, and usefulness of the method duplicates to determine various measurands on a hematology analyzer.

Cefuroxime Sodium

C023-5G 5 g
EUR 335

Cefuroxime

GA9610-100MG 100 mg
EUR 70

Cefuroxime

GA9610-1G 1 g
EUR 156

Cefuroxime

GA9610-250MG 250 mg
EUR 94

Cromolyn sodium salt

SB0843 5g
EUR 65.66

Methotrexate sodium salt

M031-250MG 250 mg
EUR 117

Monensin Sodium Salt

M083-1G 1 g
EUR 71

Monensin Sodium Salt

M083-5x1G 5 x 1 g
EUR 159

MES, sodium salt

MB0611 50g
EUR 74.36

MOPSO, sodium salt

MDB0095 25g
EUR 63.92

MOPS, sodium salt

MDB360S 100g
EUR 89.15

Entacapone (sodium salt)

HY-14280A 10mg
EUR 119

Grazoprevir sodium salt

HY-15298C 10mg
EUR 243

Luminol (sodium salt)

HY-15922A 500mg
EUR 108

Salinomycin (sodium salt)

HY-17439 100mg
EUR 187

Heparin (sodium salt)

HY-17567A 500mg
EUR 147

Seladelpar sodium salt

HY-19522A 10mM/1mL
EUR 163

Etomoxir (sodium salt)

HY-50202A 5mg
EUR 147

Silmitasertib (sodium salt)

HY-50855B 10mg
EUR 187

Cefotaxime (sodium salt)

HY-A0088 10mM/1mL
EUR 113

Adapalene (sodium salt)

HY-B0091A 500mg
EUR 326

Cefoperazone (sodium salt)

HY-B0210A 500mg
EUR 108

Sulfamerazine (sodium salt)

HY-B0512A 500mg
EUR 131

Azlocillin (sodium salt)

HY-B0529A 500mg
EUR 113

Ceftriaxone (sodium salt)

HY-B0712B 500mg
EUR 173

Citicoline sodium salt

HY-B0739A 100mg
EUR 108

Bucladesine (sodium salt)

HY-B0764 50mg
EUR 139

Cloprostenol sodium salt

HY-108415 10mg
EUR 349

Fosmidomycin sodium salt

HY-112853 5mg
EUR 349

Zidebactam sodium salt

HY-120859A 10mg
EUR 1025

Resorufin sodium salt

HY-123533A 100mg
EUR 142

Batimastat (sodium salt)

HY-13564A 5mg
EUR 187

HEPES, sodium salt

HB0265 50g
EUR 65.66

HEPPSO, sodium salt

HB0496 25g
EUR 97.85

Nigericin (sodium salt)

HY-100381 100mg
EUR 725

Setogepram (sodium salt)

HY-100775 10mM/1mL
EUR 327

GJ103 (sodium salt)

HY-101203A 10mM/1mL
EUR 142

Moniliformin (sodium salt)

HY-101905 1mg
EUR 312

Danshensu (sodium salt)

HY-N0106 200mg
EUR 291

Monensin sodium salt

HY-N0150 100mg
EUR 108

XTT, sodium salt

PB2525 250mg
EUR 269.24

PIPES, sodium salt

PDB0434 100g
EUR 88.28

Suramin (sodium salt)

HY-B0879A 50mg
EUR 394

Zomepirac (sodium salt)

HY-B0890 500mg
EUR 160

Oxacillin (sodium salt)

HY-B0925 100mg
EUR 119

Methicillin (sodium salt)

HY-B0974 10mM/1mL
EUR 126

Sulfaquinoxaline sodium salt

HY-B1282A 100mg
EUR 119

Lorglumide sodium salt

HY-B1439B 5mg
EUR 119

Moxalactam (sodium salt)

HY-B1484 200mg
EUR 147

DIDS sodium salt

HY-D0086 50mg
EUR 142

NADP (sodium salt)

HY-F0002 500mg
EUR 271

TAPS, sodium salt

TB0920 50g
EUR 71.75

TAPSO, sodium salt

TB0922 50g
EUR 102.2

MES sodium salt

GB1926-10G 10 g
EUR 50

MES sodium salt

GB1926-250G 250 g
EUR 181

MES sodium salt

GB1926-500G 500 g
EUR 298

MOPSO sodium salt

GB3228-100G 100 g
EUR 94

MOPSO sodium salt

GB3228-25G 25 g
EUR 58

MOPSO sodium salt

GB3228-500G 500 g
EUR 229

TES sodium salt

GB4016-100G 100 g
EUR 150

TES sodium salt

GB4016-500G 500 g
EUR 429

CAPSO sodium salt

GB4515-100G 100 g
EUR 110

CAPSO sodium salt

GB4515-25G 25 g
EUR 54

CAPSO sodium salt

GB4515-500G 500 g
EUR 309

MOPS sodium salt

GB8397-100G 100 g
EUR 66

MOPS sodium salt

GB8397-1KG 1 kg
EUR 257

DIPSO sodium salt

GB8985-250G 250 g
EUR 628

BES sodium salt

GB9133-25G 25 g
EUR 86

HEPES sodium salt

GB9181-250G 250 g
EUR 99

HEPES sodium salt

GB9181-500G 500 g
EUR 150

Heparin sodium salt

GC2310-100MG 100 mg
EUR 46

Heparin sodium salt

GC2310-1G 1 g
EUR 82

Heparin sodium salt

GC2310-250MG 250 mg
EUR 54

XTT sodium salt

GC5281-100MG 100 mg
EUR 205

XTT sodium salt

GC5281-250MG 250 mg
EUR 325

XTT sodium salt

GC5281-25MG 25 mg
EUR 94

XTT sodium salt

GC5281-50MG 50 mg
EUR 142

Casein sodium salt

GE5861-100G 100 g
EUR 43

Casein sodium salt

GE5861-1KG 1 kg
EUR 70

Casein sodium salt

GE5861-250G 250 g
EUR 47

Casein sodium salt

GE5861-500G 500 g
EUR 54

TAPS sodium salt

GB0912-100G 100 g
EUR 134

TAPS sodium salt

GB0912-25G 25 g
EUR 62

TAPS sodium salt

GB0912-500G 500 g
EUR 341

TAPSO sodium salt

GB1759-100G 100 g
EUR 134

TAPSO sodium salt

GB1759-25G 25 g
EUR 62

MES sodium salt

GB1926-100G 100 g
EUR 110

MES sodium salt

GB1926-25G 25 g
EUR 62

MOPSO sodium salt

GB3228-250G 250 g
EUR 150

TES sodium salt

GB4016-250G 250 g
EUR 269

TES sodium salt

GB4016-25G 25 g
EUR 70

CAPSO sodium salt

GB4515-250G 250 g
EUR 205

MOPS sodium salt

GB8397-250G 250 g
EUR 104

MOPS sodium salt

GB8397-25G 25 g
EUR 49

MOPS sodium salt

GB8397-500G 500 g
EUR 161

DIPSO sodium salt

GB8985-100G 100 g
EUR 329

DIPSO sodium salt

GB8985-25G 25 g
EUR 150

BES sodium salt

GB9133-100G 100 g
EUR 181

BES sodium salt

GB9133-250G 250 g
EUR 341

HEPES sodium salt

GB9181-100G 100 g
EUR 70

HEPES sodium salt

GB9181-1KG 1 kg
EUR 229

HEPES sodium salt

GB9181-25G 25 g
EUR 54

Ceftizoxime sodium salt

GA1247-1G 1 g
EUR 82

Ceftizoxime sodium salt

GA1247-250MG 250 mg
EUR 59

Sulfamethazine sodium salt

GA1560-100G 100 g
EUR 86

Flucloxacillin sodium salt

GA1968-100MG 100 mg
EUR 229

Flucloxacillin sodium salt

GA1968-25MG 25 mg
EUR 110

Flucloxacillin sodium salt

GA1968-5MG 5 mg
EUR 62

Sulfathiazole sodium salt

GA2698-100G 100 g
EUR 126

Sulfathiazole sodium salt

GA2698-25G 25 g
EUR 62

Sulfamethoxazole sodium salt

GA2831-25G 25 g
EUR 94

Sulfamethoxazole sodium salt

GA2831-5G 5 g
EUR 58

Cefotaxime sodium salt

GA3583-1G 1 g
EUR 110

Cefotaxime sodium salt

GA3583-25G 25 g
EUR 500

Cefotaxime sodium salt

GA3583-5G 5 g
EUR 181

Piperacillin sodium salt

GA4134-1G 1 g
EUR 70

Piperacillin sodium salt

GA4134-5G 5 g
EUR 158

Cefoxitin sodium salt

GA4412-1G 1 g
EUR 110

Cefoxitin sodium salt

GA4412-250MG 250 mg
EUR 62

Cefoxitin sodium salt

GA4412-5G 5 g
EUR 293

Cefditoren sodium salt

GA4627-1G 1 g
EUR 628

Cloxacillin sodium salt

GA4688-1G 1 g
EUR 70

Cloxacillin sodium salt

GA4688-25G 25 g
EUR 421

Cloxacillin sodium salt

GA4688-5G 5 g
EUR 174

Cefazolin sodium salt

GA4751-1G 1 g
EUR 86

Cefazolin sodium salt

GA4751-5G 5 g
EUR 174

Monensin sodium salt

GA4916-1G 1 g
EUR 78

Monensin sodium salt

GA4916-500MG 500 mg
EUR 62

Monensin sodium salt

GA4916-5G 5 g
EUR 229

Tazobactam sodium salt

GA5074-1G 1 g
EUR 150

Tazobactam sodium salt

GA5074-250MG 250 mg
EUR 78

Novobiocin sodium salt

GA5711-1G 1 g
EUR 70

Novobiocin sodium salt

GA5711-5G 5 g
EUR 166

Moxalactam sodium salt

GA5791-1G 1 g
EUR 245

Moxalactam sodium salt

GA5791-5G 5 g
EUR 548

Nigericin sodium salt

GA6233-10MG 10 mg
EUR 174

Nigericin sodium salt

GA6233-25MG 25 mg
EUR 269

Nigericin sodium salt

GA6233-5MG 5 mg
EUR 110

Cephalothin sodium salt

GA6496-1G 1 g
EUR 94

Cephalothin sodium salt

GA6496-5G 5 g
EUR 181

Rifamycin sodium salt

GA6855-1G 1 g
EUR 86

Rifamycin sodium salt

GA6855-5G 5 g
EUR 221

Sulfadiazine sodium salt

GA7306-100G 100 g
EUR 110

Ampicillin sodium salt

GA7355-100G 100 g
EUR 181

Ampicillin sodium salt

GA7355-10G 10 g
EUR 62

Ampicillin sodium salt

GA7355-1G 1 g
EUR 46

Ampicillin sodium salt

GA7355-25G 25 g
EUR 86

Ampicillin sodium salt

GA7355-5G 5 g
EUR 54

Cefpodoxime sodium salt

GA7534-100MG 100 mg
EUR 540

Ertapenem sodium salt

GA8176-100MG 100 mg
EUR 54

Ertapenem sodium salt

GA8176-1G 1 g
EUR 150

Ertapenem sodium salt

GA8176-250MG 250 mg
EUR 78

Cefoperazone sodium salt

GA8838-1G 1 g
EUR 58

Cefoperazone sodium salt

GA8838-25G 25 g
EUR 205

Cefoperazone sodium salt

GA8838-5G 5 g
EUR 102

Azlocillin sodium salt

GA9075-1G 1 g
EUR 134

Ceftiofur sodium salt

GA9758-1G 1 g
EUR 110

Zincon sodium salt

GK0303-10G 10 g
EUR 174

Zincon sodium salt

GK0303-1G 1 g
EUR 54

Zincon sodium salt

GK0303-25G 25 g
EUR 317

Zincon sodium salt

GK0303-5G 5 g
EUR 109

Pravastatin sodium salt

GK3699-50MG 50 mg
EUR 110

Saccharin sodium salt

GK7761-1KG 1 kg
EUR 110

Saccharin sodium salt

GK7761-500G 500 g
EUR 78

MCC950 sodium salt

GL1674-10MG 10 mg
EUR 551

MCC950 sodium salt

GL1674-1MG 1 mg
EUR 143

MCC950 sodium salt

GL1674-5MG 5 mg
EUR 367

Saccharin sodium salt

GK7761-100G 100 g
EUR 45

Saccharin sodium salt

GK7761-250G 250 g
EUR 58

Xanthine sodium salt

GK7942-1G 1 g
EUR 94

Xanthine sodium salt

GK7942-250MG 250 mg
EUR 59

Suramin sodium salt

GP0138-250MG 250 mg
EUR 309

Suramin sodium salt

GP0138-50MG 50 mg
EUR 110

Dantrolene sodium salt

GP0222-1G 1 g
EUR 94

Dantrolene sodium salt

GP0222-5G 5 g
EUR 181

Amoxicillin sodium salt

GP0775-1G 1 g
EUR 50

Amoxicillin sodium salt

GP0775-5G 5 g
EUR 102

Naproxen sodium salt

GP1072-25G 25 g
EUR 130

Naproxen sodium salt

GP1072-5G 5 g
EUR 78

Warfarin sodium salt

GP6872-10G 10 g
EUR 86

Warfarin sodium salt

GP6872-25G 25 g
EUR 126

Warfarin sodium salt

GP6872-5G 5 g
EUR 62

Cilastatin sodium salt

GP8376-100MG 100 mg
EUR 221

Cromolyn sodium salt

GP8420-1G 1 g
EUR 54

Cromolyn sodium salt

GP8420-25G 25 g
EUR 181

Cromolyn sodium salt

GP8420-5G 5 g
EUR 94

Fluvastatin sodium salt

GP9431-1G 1 g
EUR 94

Cloprostenol sodium salt

GP9491-5MG 5 mg
EUR 158

Diclofenac sodium salt

GP9539-25G 25 g
EUR 86

Diclofenac sodium salt

GP9539-5G 5 g
EUR 54


Data from 1164 patients admitted to our Department of Urology from January 2011 to July 2013 were retrospectively reviewed; 714 patients (age, 5-87 years; male: female ratio, 1.8: 1) exhibited urolithiasis, and 450 patients (age, 12-94 years; male: female ratio, 3.8: 1). Blood and urine are collected from patients morning after hospital admission. Serum and urine parameters examined by automatic biochemical analyzer. Statistical analyzes including Mann-Whitney U test and binary logistic regression.

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