IMPORTANCE OF ZINC CONCENTRATION IN SEMINAL FLUID OF MEN DIAGNOSED WITH INFERTILITY
The prevalence and importance of male infertility makes medical and social problems that seriously throughout the world. The purpose of this study was to determine whether there is a significant difference in the concentration of zinc in seminal fluid in men diagnosed with infertility compared with the control group, and if there is, to determine how it affects the number and percentage of sperm motility were normal and morphology.
A case-control study conducted in Osijek-Baranja County from January 2014 to June 2015. The study included 276 subjects called biochemical laboratory of Osijek University Central Hospital, 100 (36.2%) of those with a low sperm count was confirmed by spermiogram after 3 months. the semen sample is processed in accordance with the criteria of the World Health Organization, and the zinc concentration was determined by spectrophotometry and colorimetric directly without deproteinization on chemical analysis (Olympus AU 680, Beckman Coulter, Tokyo, Japan).
The study shows that men with low sperm counts were significantly older (Mann Whitney U test: p = 0.013) and had lower levels of zinc (χ2-test: p <0.001). Further analysis included 100 (36.2%) patients with low sperm count. In the group of infertile men, men with low sperm counts have higher levels of zinc compared with men with azoospermia (Mann Whitney U test: p = 0.036), indicating a relationship between low zinc levels in the fertility of male fluid and semen.
Zinc as biological markers and antioxidants affect the sperm count, motility and morphology. Therapeutic zinc supplements may improve semen parameters in patients diagnosed with a low sperm count. dietary habits of different regional subjects, and future research can create a solid foundation for complementary approach to the treatment of male infertility.
IMPORTANCE OF ZINC CONCENTRATION IN SEMINAL FLUID OF MEN DIAGNOSED WITH INFERTILITY
Effect of broiler genetics, age, and gender on performance and blood chemistry
A total of 640 broilers were used to determine the effects of strain, sex, and age on hematology and blood chemistry using a rapid detection. Day old chicks from two genetic lines of the common broiler strains of fast-growing and high yield sexed and allocated to 40 pens (16 birds per pen) containing either male or female and Ross or Cobb strains (n = 10). Venous blood was analyzed weekly using 2 broilers from each pen (n = 20) using the Clinical Analyzer i-STAT® Alinity Handheld, Zoetis Vetscan VS2, and the device iCheck ™ Carotene at 14, 21, 28, 35, and 42 d, as as well as growth performance. Post-mortem health tracking metrics is also recorded on 42 d. Broiler considered healthy based on data posts and conducted in accordance with industry standards by males presenting a larger BW and reduced FCR of broilers women.
Ross broiler larger display BW for 14 d with the same FCR compared to Cobb birds. Days of age had a very significant impact on blood calcium, phosphorus, potassium, sodium, chloride, carotene, aspartate aminotransferase, creatine kinase, bile acid, uric acid, total protein, albumin, globulin, total carbon dioxide, hematocrit, and malondialdehyde. male broilers had reduced blood sodium, chloride, carotene, uric acid, albumin, and increased total protein, glucose, and total carbon dioxide.
Description: Enzyme-linked immunosorbent assay kit for quantification of General Histamine in samples from serum, plasma, tissue homogenates and other biological fluids.
Description: Quantitative sandwich ELISA for measuring Mouse Histamine in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.
Description: Quantitative sandwich ELISA for measuring Mouse Histamine in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.
Description: Quantitative sandwich ELISA for measuring Mouse Histamine in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.
Description: Quantitative sandwich ELISA for measuring Human Histamine in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.
Description: Quantitative sandwich ELISA for measuring Human Histamine in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.
Description: Quantitative sandwich ELISA for measuring Human Histamine in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.
Description: Quantitative sandwich ELISA for measuring Rat Histamine in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.
Description: Quantitative sandwich ELISA for measuring Rat Histamine in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.
Description: Quantitative sandwich ELISA for measuring Rat Histamine in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.
Description: A competitive Inhibition ELISA kit for detection of Histamine from General in samples from blood, serum, plasma, cell culture fluid and other biological fluids.
Description: A competitive Inhibition ELISA kit for detection of Histamine from General in samples from blood, serum, plasma, cell culture fluid and other biological fluids.
Description: PPACK Dihydrochloride is the dihydrochloride form of its active component PPACK (D-Phenylalanyl-L-prolyl-L-arginine chloromethyl ketone), a potent, selective and irreversible inhibitor of thrombin that inhibits human ?-thrombin with inhibition constant Kivalue of 0.24 nM.
Description: PPACK Dihydrochloride is the dihydrochloride form of its active component PPACK (D-Phenylalanyl-L-prolyl-L-arginine chloromethyl ketone), a potent, selective and irreversible inhibitor of thrombin that inhibits human ?-thrombin with inhibition constant Kivalue of 0.24 nM.
Description: PPACK Dihydrochloride is the dihydrochloride form of its active component PPACK (D-Phenylalanyl-L-prolyl-L-arginine chloromethyl ketone), a potent, selective and irreversible inhibitor of thrombin that inhibits human ?-thrombin with inhibition constant Kivalue of 0.24 nM.
Description: IC50: AKT1 32 nM, AKT2 17 nM, AKT3 47 nM, PKA 20 nMThe serine/threonine kinase AKT plays a pivotal role in signal transduction events involved in malignant transformation and chemoresistance and is an attractive target for the development of cancer therapeutics.
Description: IC50: AKT1 32 nM, AKT2 17 nM, AKT3 47 nM, PKA 20 nMThe serine/threonine kinase AKT plays a pivotal role in signal transduction events involved in malignant transformation and chemoresistance and is an attractive target for the development of cancer therapeutics.
Description: IC50: AKT1 32 nM, AKT2 17 nM, AKT3 47 nM, PKA 20 nMThe serine/threonine kinase AKT plays a pivotal role in signal transduction events involved in malignant transformation and chemoresistance and is an attractive target for the development of cancer therapeutics.
Description: IC50: AKT1 32 nM, AKT2 17 nM, AKT3 47 nM, PKA 20 nMThe serine/threonine kinase AKT plays a pivotal role in signal transduction events involved in malignant transformation and chemoresistance and is an attractive target for the development of cancer therapeutics.
Description: IC50: AKT1 32 nM, AKT2 17 nM, AKT3 47 nM, PKA 20 nMThe serine/threonine kinase AKT plays a pivotal role in signal transduction events involved in malignant transformation and chemoresistance and is an attractive target for the development of cancer therapeutics.
Description: Canertinib dihydrochloride is a selective inhibitor of Pan-erbB tyrosine kinase with IC50 value of 3.5 nM [1].ErbB receptor family is a member of the receptor tyrosine kinase superfamily and plays an important role in the normal breast development.
Description: Canertinib dihydrochloride is a selective inhibitor of Pan-erbB tyrosine kinase with IC50 value of 3.5 nM [1].ErbB receptor family is a member of the receptor tyrosine kinase superfamily and plays an important role in the normal breast development.
Description: Canertinib dihydrochloride is a selective inhibitor of Pan-erbB tyrosine kinase with IC50 value of 3.5 nM [1].ErbB receptor family is a member of the receptor tyrosine kinase superfamily and plays an important role in the normal breast development.
Description: Description:IC50 Value: 0.8 nM [1]Inolitazone(RS5444) is a novel high-affinity PPARgamma agonist, which activates PPARgamma with an EC50 about 1/50th that of rosiglitazone and has no effect on RIE cells that do not express PPARgamma.
Description: Selective inhibitor of protein tyrosine phosphatases localized to mitochondrion 1 (PTPMT1) (IC50 = 1.08 ?M in vitro). Stimulates increased insulin secretion by ?-cells in rat pancreatic islets. Displays antitcancer properties in FaDu cells.
Description: Selective inhibitor of protein tyrosine phosphatases localized to mitochondrion 1 (PTPMT1) (IC50 = 1.08 ?M in vitro). Stimulates increased insulin secretion by ?-cells in rat pancreatic islets. Displays antitcancer properties in FaDu cells.
Description: LDK378 is a highly potent inhibitor of anaplastic lymphoma kinase (ALK), which is a receptor tyrosine kinase belonging to the superfamily of insulin receptor, with half maximal inhibitory concentration IC50 of 200 pM.
Description: LDK378 is a highly potent inhibitor of anaplastic lymphoma kinase (ALK), which is a receptor tyrosine kinase belonging to the superfamily of insulin receptor, with half maximal inhibitory concentration IC50 of 200 pM.
Description: LDK378 is a highly potent inhibitor of anaplastic lymphoma kinase (ALK), which is a receptor tyrosine kinase belonging to the superfamily of insulin receptor, with half maximal inhibitory concentration IC50 of 200 pM.
Description: LDK378 is a highly potent inhibitor of anaplastic lymphoma kinase (ALK), which is a receptor tyrosine kinase belonging to the superfamily of insulin receptor, with half maximal inhibitory concentration IC50 of 200 pM.
Description: LDK378 is a highly potent inhibitor of anaplastic lymphoma kinase (ALK), which is a receptor tyrosine kinase belonging to the superfamily of insulin receptor, with half maximal inhibitory concentration IC50 of 200 pM.
Description: Mibefradil is calcium channel blocker with moderate selectivity for T-type Ca2+ channels displaying IC50 values of 2.7 ?M and 18.6 ?M for T-type and L-type channels respectively. Mibefradil is antihypertensive agent for the treatment of hypertension and chronic angina pectoris.
Description: Mibefradil is calcium channel blocker with moderate selectivity for T-type Ca2+ channels displaying IC50 values of 2.7 ?M and 18.6 ?M for T-type and L-type channels respectively. Mibefradil is antihypertensive agent for the treatment of hypertension and chronic angina pectoris.
Description: Mibefradil is calcium channel blocker with moderate selectivity for T-type Ca2+ channels displaying IC50 values of 2.7 ?M and 18.6 ?M for T-type and L-type channels respectively. Mibefradil is antihypertensive agent for the treatment of hypertension and chronic angina pectoris.
Description: Mibefradil is calcium channel blocker with moderate selectivity for T-type Ca2+ channels displaying IC50 values of 2.7 ?M and 18.6 ?M for T-type and L-type channels respectively. Mibefradil is antihypertensive agent for the treatment of hypertension and chronic angina pectoris.
Description: Pramipexole dihydrochloride is a dopamine receptor agonist with selectivity for the D3 receptor (Ki values are 3.9, 3.3, 0.5 and 3.9 nM for D2L, D2S, D3 and D4 receptors respectively). Pramipexole dihydrochloride exhibits negligable affinity for D1 and D5 receptors.
Description: Pramipexole dihydrochloride is a dopamine receptor agonist with selectivity for the D3 receptor (Ki values are 3.9, 3.3, 0.5 and 3.9 nM for D2L, D2S, D3 and D4 receptors respectively). Pramipexole dihydrochloride exhibits negligable affinity for D1 and D5 receptors.
Description: Pramipexole dihydrochloride is a dopamine receptor agonist with selectivity for the D3 receptor (Ki values are 3.9, 3.3, 0.5 and 3.9 nM for D2L, D2S, D3 and D4 receptors respectively). Pramipexole dihydrochloride exhibits negligable affinity for D1 and D5 receptors.
Description: Veliparib dihydrochloride is a potent inhibitor of PARP-1 and PARP-2 with K (i) s of 5.2 and 2.9 nmol/L, respectively [1].PARP is short of poly ADP ribose polymerase and is reported as an overexpressed enzyme in a variety of cancers.
Description: Veliparib dihydrochloride is a potent inhibitor of PARP-1 and PARP-2 with K (i) s of 5.2 and 2.9 nmol/L, respectively [1].PARP is short of poly ADP ribose polymerase and is reported as an overexpressed enzyme in a variety of cancers.
Description: Veliparib dihydrochloride is a potent inhibitor of PARP-1 and PARP-2 with K (i) s of 5.2 and 2.9 nmol/L, respectively [1].PARP is short of poly ADP ribose polymerase and is reported as an overexpressed enzyme in a variety of cancers.
Description: Veliparib dihydrochloride is a potent inhibitor of PARP-1 and PARP-2 with K (i) s of 5.2 and 2.9 nmol/L, respectively [1].PARP is short of poly ADP ribose polymerase and is reported as an overexpressed enzyme in a variety of cancers.
Description: Veliparib dihydrochloride is a potent inhibitor of PARP-1 and PARP-2 with K (i) s of 5.2 and 2.9 nmol/L, respectively [1].PARP is short of poly ADP ribose polymerase and is reported as an overexpressed enzyme in a variety of cancers.
Description: IT1t dihydrochloride is a potent antagonist of CXCR4 with IC50 value of 8.0 nM [1]. C-X-C chemokine receptor type 4 (CXCR4) is an ?-chemokine receptor for chemokine CXCL12.
Description: IT1t dihydrochloride is a potent antagonist of CXCR4 with IC50 value of 8.0 nM [1]. C-X-C chemokine receptor type 4 (CXCR4) is an ?-chemokine receptor for chemokine CXCL12.
Description: IT1t dihydrochloride is a potent antagonist of CXCR4 with IC50 value of 8.0 nM [1]. C-X-C chemokine receptor type 4 (CXCR4) is an ?-chemokine receptor for chemokine CXCL12.
Description: IT1t dihydrochloride is a potent antagonist of CXCR4 with IC50 value of 8.0 nM [1]. C-X-C chemokine receptor type 4 (CXCR4) is an ?-chemokine receptor for chemokine CXCL12.
Description: IT1t dihydrochloride is a potent antagonist of CXCR4 with IC50 value of 8.0 nM [1]. C-X-C chemokine receptor type 4 (CXCR4) is an ?-chemokine receptor for chemokine CXCL12.
Description: IT1t dihydrochloride is a potent antagonist of CXCR4 with IC50 value of 8.0 nM [1]. C-X-C chemokine receptor type 4 (CXCR4) is an ?-chemokine receptor for chemokine CXCL12.
Description: EC50: 1.24 ?MFluphenazine is a dopamine D1 and D2 receptor inhibitor.Dopamine D1 and D2 receptor immunohistochemistry has been used to study the structure of the adult rat arcuate-median eminence complex, particularly in relation to the tubero-infundibular dopamine neurons.
Description: EC50: 1.24 ?MFluphenazine is a dopamine D1 and D2 receptor inhibitor.Dopamine D1 and D2 receptor immunohistochemistry has been used to study the structure of the adult rat arcuate-median eminence complex, particularly in relation to the tubero-infundibular dopamine neurons.
Description: 1400W dihydrochloride is a potent and selective inhibitor of inducible nitric oxide synthase with Kd value of 7 nM [1]. Inducible nitric oxide synthase (iNOS) is an enzyme catalyzing the production of nitric oxide (NO) and is involved in immune response.
Description: 1400W dihydrochloride is a potent and selective inhibitor of inducible nitric oxide synthase with Kd value of 7 nM [1]. Inducible nitric oxide synthase (iNOS) is an enzyme catalyzing the production of nitric oxide (NO) and is involved in immune response.
Description: 1400W dihydrochloride is a potent and selective inhibitor of inducible nitric oxide synthase with Kd value of 7 nM [1]. Inducible nitric oxide synthase (iNOS) is an enzyme catalyzing the production of nitric oxide (NO) and is involved in immune response.
Description: Mizolastine dihydrochloride is a histamine H1-receptor antagonist with IC50 of 47 nM used in the treatment of hay fever (seasonal allergic rhinitis), hives and other allergic reactions.
Description: Mizolastine dihydrochloride is a histamine H1-receptor antagonist with IC50 of 47 nM used in the treatment of hay fever (seasonal allergic rhinitis), hives and other allergic reactions.
Description: Mizolastine dihydrochloride is a histamine H1-receptor antagonist with IC50 of 47 nM used in the treatment of hay fever (seasonal allergic rhinitis), hives and other allergic reactions.
Description: MIC: 10-100 ?g/mL in most of the strainsFlupenthixol, introduced in 1965 by Lundbeck, marketed under brand names such asDepixol.Flupenthixolis atypical antipsychoticdrugof thethioxantheneclass.
Description: Vanoxerine is an antagonist of dopamine transporter (DAT1) with Ki value of 16.9nM [1].As an antagonist of DAT, vanoxerine is developed for treatment of Parkinson's disease and depression but has no effect on these diseases.
Description: Vanoxerine is an antagonist of dopamine transporter (DAT1) with Ki value of 16.9nM [1].As an antagonist of DAT, vanoxerine is developed for treatment of Parkinson's disease and depression but has no effect on these diseases.
Description: Vanoxerine is an antagonist of dopamine transporter (DAT1) with Ki value of 16.9nM [1].As an antagonist of DAT, vanoxerine is developed for treatment of Parkinson's disease and depression but has no effect on these diseases.
Ross broilers had greater blood potassium, and sodium, as well as reduce uric acid, total protein, globulin, and malondialdehyde, compared to Cobb birds. These results demonstrate the effectiveness of point-of-care device for measuring blood chemistry and hematology in the modern broiler. This data can be used to determine normal ranges of healthy blood in this kind of broiler when accounting for the strain, sex, and age.
