IMPORTANCE OF ZINC CONCENTRATION IN SEMINAL FLUID OF MEN DIAGNOSED WITH INFERTILITY
The prevalence and importance of male infertility makes medical and social problems that seriously throughout the world. The purpose of this study was to determine whether there is a significant difference in the concentration of zinc in seminal fluid in men diagnosed with infertility compared with the control group, and if there is, to determine how it affects the number and percentage of sperm motility were normal and morphology.
A case-control study conducted in Osijek-Baranja County from January 2014 to June 2015. The study included 276 subjects called biochemical laboratory of Osijek University Central Hospital, 100 (36.2%) of those with a low sperm count was confirmed by spermiogram after 3 months. the semen sample is processed in accordance with the criteria of the World Health Organization, and the zinc concentration was determined by spectrophotometry and colorimetric directly without deproteinization on chemical analysis (Olympus AU 680, Beckman Coulter, Tokyo, Japan).
The study shows that men with low sperm counts were significantly older (Mann Whitney U test: p = 0.013) and had lower levels of zinc (χ2-test: p <0.001). Further analysis included 100 (36.2%) patients with low sperm count. In the group of infertile men, men with low sperm counts have higher levels of zinc compared with men with azoospermia (Mann Whitney U test: p = 0.036), indicating a relationship between low zinc levels in the fertility of male fluid and semen.
Zinc as biological markers and antioxidants affect the sperm count, motility and morphology. Therapeutic zinc supplements may improve semen parameters in patients diagnosed with a low sperm count. dietary habits of different regional subjects, and future research can create a solid foundation for complementary approach to the treatment of male infertility.
IMPORTANCE OF ZINC CONCENTRATION IN SEMINAL FLUID OF MEN DIAGNOSED WITH INFERTILITY
Effect of broiler genetics, age, and gender on performance and blood chemistry
A total of 640 broilers were used to determine the effects of strain, sex, and age on hematology and blood chemistry using a rapid detection. Day old chicks from two genetic lines of the common broiler strains of fast-growing and high yield sexed and allocated to 40 pens (16 birds per pen) containing either male or female and Ross or Cobb strains (n = 10). Venous blood was analyzed weekly using 2 broilers from each pen (n = 20) using the Clinical Analyzer i-STAT® Alinity Handheld, Zoetis Vetscan VS2, and the device iCheck ™ Carotene at 14, 21, 28, 35, and 42 d, as as well as growth performance. Post-mortem health tracking metrics is also recorded on 42 d. Broiler considered healthy based on data posts and conducted in accordance with industry standards by males presenting a larger BW and reduced FCR of broilers women.
Ross broiler larger display BW for 14 d with the same FCR compared to Cobb birds. Days of age had a very significant impact on blood calcium, phosphorus, potassium, sodium, chloride, carotene, aspartate aminotransferase, creatine kinase, bile acid, uric acid, total protein, albumin, globulin, total carbon dioxide, hematocrit, and malondialdehyde. male broilers had reduced blood sodium, chloride, carotene, uric acid, albumin, and increased total protein, glucose, and total carbon dioxide.
Description: Histamine-α,α,β,β-d4 (dihydrochloride) is the deuterium labeled Histamine. Histamine is an organic nitrogenous compound involved in local immune responses as well as regulating physiological function in the gut and acting as a neurotransmitter.
Description: SMARCA-BD ligand 1 for Protac dihydrochloride is a compound that binds to the BAF ATPase subunits SMARCA2, and used for degrading SMARCA2, based on PROTAC[1].
Description: MPP dihydrochloride is a potent and selective ER (estrogen receptor) modulator. MPP dihydrochloride induces significant apoptosis in the endometrial cancer and oLE cell lines. MPP dihydrochloride reverses the positive effects of beta-estradiol. MPP dihydrochloride has mixed agonist/antagonist action on murine uterine ERalpha in vivo[1][2][3].
Description: SAG dihydrochloride is a potent Smoothened (Smo) receptor agonist (EC50=3 nM; Kd=59 nM). SAG dihydrochloride activates the Hedgehog signaling pathway and counteracts Cyclopamine (HY-17024) inhibition of Smo[1][2][3].
Description: IT1t dihydrochloride is a potent antagonist of CXCR4 with IC50 value of 8.0 nM [1]. C-X-C chemokine receptor type 4 (CXCR4) is an ?-chemokine receptor for chemokine CXCL12.
Description: PB28 dihydrochloride, a cyclohexylpiperazine derivative, is a high affinity and selective sigma 2 (σ2) receptor agonist with a Ki of 0.68 nM. PB28 dihydrochloride is also a σ1 antagonist with a Ki of 0.38 nM. PB28 dihydrochloride is less affinity for other receptors. PB28 dihydrochloride inhibits electrically evoked twitch in guinea pig bladder and ileum with EC50 values of 2.62 μM and 3.96 μM, respectively. PB28 dihydrochloride can modulate SARS-CoV-2-human protein-protein interaction. PB28 dihydrochloride induces caspase-independent apoptosis and has antitumor activity[1][2][3][4][5].
Description: DMPQ dihydrochloride is a potent and selective inhibitor of human platelet-derived growth factor receptor β (PDGFRβ) with an IC50 of 80 nM[1].
Description: Y13g dihydrochloride is the potent inhibitor of both AChE and IL-6. Interleukin-6 (IL-6) and acetylcholinesterase (AChE) are two important targets implicated in progression of Alzheimer's Disease (AD). Y13g dihydrochloride reverses the STZ-induced memory deficit, and shows histopathology similarly as in normal animals[1].
Description: TD52 dihydrochloride, an Erlotinib (HY-50896) derivative, is an orally active, potent cancerous inhibitor of protein phosphatase 2A (CIP2A) inhibitor. TD52 dihydrochloride mediates the apoptotic effect in triple-negative breast cancer (TNBC) cells via regulating the CIP2A/PP2A/p-Akt signalling pathway. TD52 dihydrochloride indirectly reduced CIP2A by disturbing Elk1 binding to the CIP2A promoter. TD52 dihydrochloride has less p-EGFR inhibition and has potent anti-cancer activity[1]. TD52 (dihydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Ross broilers had greater blood potassium, and sodium, as well as reduce uric acid, total protein, globulin, and malondialdehyde, compared to Cobb birds. These results demonstrate the effectiveness of point-of-care device for measuring blood chemistry and hematology in the modern broiler. This data can be used to determine normal ranges of healthy blood in this kind of broiler when accounting for the strain, sex, and age.
