Objective: To explore the association of the concentration of urinary phenols and blood biochemical indices in coke oven workers. Methods: From April to May 2019, we examined 771 workers ‘coke workers’ employees from a Coke power plant in Taiyuan City and classified in a group exposed to benzene (n = 402) and the control group ( n = 369) according to their exposures to benzene in the workplace and concentrations of uophenol. All subjects were interviewed in the face-to-face using a questionnaire, including the name, age (year), sex, smoking and beverage habits, personal professional history, The working length (year) and professional protection, etc. Post-Shift urine samples detected a chromatography ionization detector in hydrogen gas chromatography.
The blood coming from fasting was drawn in the morning and centrifuged, the separate serum was detected the following elements using an automatic blood biochemistry analyzer. Covariance and multiple linear regression were used to test the association of urinary phenol concentration and the levels of all blood biochemical indices. Results: Subjects were mainly men (n = 719, 93.3%), with an average age of (42.3 ± 8.2.2) years and an average working length of (20.6 ± 8, 2.2) years.
Compared to the control group, the group exposed to benzene was significantly different from the age, life of the years, gender, smoking and beverage habits (p <0.05). The median concentration (interquartile interval) of the urinary phenol was 6.00 (0.00-33.00) μg / ml in the group exposed to benzene, which was significantly greater than that of the control group (p <0.05) . The analysis of covariance indicated that fasting blood glucose, total cholesterol and high density cholesterol in the group exposed to benzene were considerably reduced in relation to the control group, but serum creatinine, serum acid uric and the triglycerides were considerably increased (p <0.05).
Castration aggravates insulin resistance, reduces immune function and improve the quality of life of prostate cancer patients
Objective: To study the influence of the castration on insulin resistance, the quality of life and the immune function of patients with prostate cancer (PCA).
Methods: A total of 57 PCA patients has definitely diagnosed via prostate biopsy suffered bilateral orchiectomy. No patient had the story of sweet diabetes before the operation. Hemoglobin, the number of leukocytes, the number of platelets, albumin and alkaline phosphatase in the blood before the operation and 1 year after the operation were analyzed using a complete biochemistry analyzer and neutrophil / lymphocyte ratio (NLR) and platelet / lymphocyte ratio (PLR)) in the peripheral blood were calculated.
Results: Serum (T) and free testosterone testosterone (FT) levels in PCA patients have decreased considerably at 1 month after castration. Compared to those before use, serum t and ft levels have been significantly reduced to 1, 2, 4 and 8 months, as well as 1 year after castration. Triglyceride levels (TG), total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) were gradually raised with the extension of time after the operation. The high-density lipoprotein cholesterol level (HDL-C) displayed an apparent three-month trend after surgical castration. The results of the flow cytometry indicated that the levels of differentiation clusters (CD) 4+ and CD4 + / CD8 + have been markedly marked while that of CD8 + has been significantly high compared to Those before castration (p <0.05) after the castration, both of the blood to fast the insulin of glucose and fasting have evidently increased in patients (p <0.05). The blood glucose and insulin of the 2 hp postprandial blood were identified separately at 1 month after castration (p <0.05). The insulin resistance index has been increased persistently and evidently (p <0.05).
[Association of Urinary Phenol Concentration and Blood Biochemical Indices in Coke Oven Workers]
Establishment of reference intervals of biochemical analytes for healthy Chinese volunteers during the clinical pharmacology test screening process
OBJECTIVE: Laboratory reference intervals (RIS) play a key role in clinical pharmacology tests, both in the screening process and in the assessment of drug safety. However, rising rises to be limited to the general population and risk data for the trial population are limited. The purpose of this study was to determine the appropriate rises to use during the projection of a defined special sub-group of a healthy Chinese population in clinical pharmacology tests.
Methods: A total of 773 healthy Chinese volunteers (552 men and 221 women) who sought to participate in clinical pharmacology tests were included in this study. Sixteen different biochemical analytes were measured by a Beckman Coulter Unicel DXC 800 automatic analyzer. The RIS was partitioned by sex using the Harris and Boyd method and calculated using a non-parametric method.
Results: The RIS of 16 biochemical analytes for healthy Chinese volunteers during the clinical pharmacology test screening process are reported in this study. Notable differences between the RIS in this study and RIS provided by our existing laboratory or literature were also observed. Compared to our institutional risks, the newly established risks were more applicable to the current trial population.
Conclusions: The RIS of this study can serve as a powerful clinical tool in the clinical pharmacology testing process. However, these rises should be re-verified if a condition changes. The results also highlight the importance of restoring risks that are more applicable to local criteria populations.
Description: Lissamine rhodamine B is a red-fluorescent dye, it is a derivative of rhodamine. Lissamine rhodamine B can be used as a fluorescent probe to develop competitive aptamer fluorescence anisotropy/polarization (FA/FP) assays[1][2].
Description: Rhodamine B hydrazide is a good probe for sulfite, with colorless and non-fluorescent properties. While the emission is related to the concentration of sulfite (5-800 ng/mL; detection limit=1.4 ng/mL (3σ)). Sulfite reduces dissolved oxygen to yield superoxide radicals, which binds to Rhodamine B hydrazide to form Rhodamine B. Rhodamine B hydrazide gives Rhodamine B-like fluorescence in the presence of sulfite, which is enhanced by Tween 80 surfactant micelles. Rhodamine B hydrazide has an absorption maximum at 554 nm and a fluorescence emission maximum at 574 nm[1].
Description: Rhodamine B isothiocyanate (RBITC) is a fluorescent dye commonly used in biological imaging and labeling applications. It has an isothiocyanate functional group that can be covalently attached to amino groups on proteins and other biomolecules, making it useful for fluorescent labeling of cells and tissues. RBITC fluoresces bright orange-red under green light excitation, which makes it easy to detect and track labeled molecules in complex samples. Due to its stability and sensitivity, RBITC has been widely used in various research fields, including cell biology, immunology, and neurobiology.
Two national dewater cats have been presented with anorexia and dehydration after the ingestion of caramelized onions. The main conclusions of a CBC (AVIA 2120), serum biochemistry and urine analysis included false and marked leukocytosis with basophil (Baso) and peroxidase channel numbers, normal number of manual leukocytes, Light and non-regenerative anemia with divergences between automated and the manual number of reticulocytes, an abundance of great Heinz bodies (HBS) and very irregular spatterngrams. The housing 1 has also demonstrated a concentration of high average corpuscular hemoglobin (MCHC) and discrepancing between RBC hemoglobin indices.
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